Age-Related Histological Changes in the Canine Substantia Nigra.
نویسندگان
چکیده
منابع مشابه
Age-Mediated Transcriptomic Changes in Adult Mouse Substantia Nigra
Substantia nigra pars compacta (SNpc) is highly sensitive to normal aging and selectively degenerates in Parkinson's disease (PD). Until now, molecular mechanisms behind SNpc aging have not been fully investigated using high throughput techniques. Here, we show early signs of aging in SNpc, which are more evident than in ventral tegmental area (VTA), a region adjacent to SNpc but less affected ...
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Background and Objective: Parkinson’s disease (PD) is a rather common neurological disorder in elders that is due to degeneration of dopaminergic neurons within mesencephalic substantia nigra pars compacta. With regard to protective and antioxidant effect of simvastatin, this study was conducted to evaluate its neuroprotective effect in an experimental model of PD. Materials and Methods: In thi...
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REFERENCES 1. BALY, F. A., History ofSouthport, Southport, Angus Downie, 1955, p. 37. 2. BmuxmHourr, J., An Essay on the Bite of a Mad Dog, London, R. Baldwin, 1783. 3. British Museum, Add. MS. 36876. 4. FoHRGLL, J., 'The Case of a Hydrophobia', in: Medical Observations and Enquiries, 2nd ed., 1779, vol. 5, p. 195. 5. HBYSHAM, J., Dissertatio Medica de Rabie Canina, Edinburgh, 1777. Information...
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In this study, age-dependent histological changes in the kidneys of Brown Norway rat, a strain useful for conducting aging research, were evaluated. Examination was performed at 3, 12, 18, 24 and 30 months of age. Sclerotic and hypertrophic changes of the glomeruli were observed, and quantitative scores of these changes persistently increased with age. A marginal increase in scores was observed...
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The substantia nigra (SN) is known to be involved in the memorization of several conditioned responses. To investigate the role of the SN in fear conditioning consolidation this neural site was subjected to fully reversible tetrodotoxin (TTX) inactivation during consolidation in adult male Wistar rats which had undergone fear training to acoustic CS and context. TTX was stereotaxically administ...
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ژورنال
عنوان ژورنال: Journal of Veterinary Medical Science
سال: 2003
ISSN: 0916-7250,1347-7439
DOI: 10.1292/jvms.65.179